郑炜 研究员 博士生导师
广东省生物医学光学影像技术重点实验室 主任
中科院深圳先进院生物医学光学研究中心 主任
中科院深圳先进技术研究院 医工所 副所长
电子邮件： [email protected]
电话号码： 0755-86392240
通信地址： 深圳市南山区西丽学苑大道1068号 B602
研究领域
生物光子学、生物光学成像技术研究及其在生物医学中的应用
教育经历
工作经历
2016\10~现在 中科院深圳先进技术研究院, 研究员
2015\10~2016\05 美国国立卫生研究院, 访问学者
2011\06~2016\10 中科院深圳先进技术研究院, 副研究员
所获奖励
2022 深圳市技术发明二等奖
2020 深圳市杰出青年基金
2018 国家自然科学基金优秀青年基金
2017 广东省特支计划科技创新领军人才
2014 广东省特支计划青年拔尖人才
2011 深圳市孔雀计划海外引进高层次人才
发表论文
2024
1. Yufeng Gao, Feng Xiang, Jia Yu, Ting Wu, Jiuling Liao, Hui Li, Shiwei Ye*, and Wei Zheng*, "Accurate piecewise centroid calculation algorithm for wavefront measurement in adaptive optics", Optics Express, 32(1): 301-312, (2024).
2. Ting Wu#, Jiuling Liao#, Feng Xiang, Jia Yu, Yinwen Huo, Yufeng Gao, Hui Li*, and Wei Zheng*, "Probing cell metabolism using the two-photon excitation autofluorescence lifetime of Tryptophan", Optics Letters, 49(5): 1105-1108, (2024).
2023
1. Yuezhi He, Jing Yao, Lina Liu, Yufeng Gao, Jia Yu, Shiwei Ye, Hui Li, and Wei Zheng*, "Self-Supervised Deep Learning Two-Photon Microscopy", Photonics Research,11(1): 1-11, (2023).
2. Shiwei Ye#, Junjie Zou#, Chenming Huang, Feng Xiang, Zonghua Wen, Nannan Wang, Jia Yu, Yuezhi He, Peng Liu, Xin Mei, Hui Li, Lili Niu, Peng Gong, and Wei Zheng*, "Rapid and label-free histological imaging of unprocessed surgical tissues via Dark-field Reflectance Ultraviolet Microscopy", iScience, 26(1): 105849, (2023).
3. Ting Wu, Jiuling Liao, Feng Xiang, Jia Yu, Yufeng Gao, Lina Liu, Shiwei Ye, Hui Li*, Kebin Shi* and Wei Zheng*, "Short-wavelength excitation two-photon intravital microscopy of endogenous fluorophores", Biomedical Optics Express, 14(7): 3380-3396, (2023).
4. Feng Xiang#, Jia Yu#, Danling Jiang, Weiwang Hu, Rongli Zhang, Chenming Huang, Ting Wu, Yufeng Gao, Aiping Zheng, Tzu-ming Liu, Wei Zheng*, Xi Li*, and Hui Li*, "Quantitative multiphoton imaging of cell metabolism, stromal fibers, and keratinization enables label-free discrimination of esophageal squamous cell carcinoma", Biomedical Optics Express, 14(8): 4137-4155, (2023).
2022
1. Lina Liu#, Xianyuan Xia#, Feng Xiang, Yufeng Gao, Xi Li, Hui Li*, and Wei Zheng*, "F-CUBIC: a rapid optical clearing method optimized by quantitative evaluation", Biomedical Optics Express, 13(1): 237-251, (2022).
2. Jing Yao, Yufeng Gao, Yixuan Yin, Puxiang Lai, Shiwei Ye*, and Wei Zheng*, "Exploiting the potential of commercial objectives to extend the field-of-view of two-photon microscopy by adaptive optics", Optics Letters, 47(4): 989-992, (2022).
3. Yufeng Gao#, Xianyuan Xia#, Lina Liu, Ting Wu, Tingai Chen, Jia Yu, Zhili Xu, Liang Wang, Fei Yan, Zhuo Du, Jun Chu, Yang Zhan, Bo Peng, Hui Li* and Wei Zheng*, "Axial gradient excitation accelerates volumetric imaging of two-photon microscopy", Photonics Research, 10(3): 687-696, (2022).
4. Ningbo Chen#, Jia Yu#, Liangjian Liu#, Zhiqiang Xu, Rongkang Gao, Tao Chen, Liang Song, Wei Zheng*, and Chengbo Liu*, "Video-rate high-resolution single-pixel nonscanning photoacoustic microscopy", Biomedical Optics Express, 13(7): 3823-3835, (2022).
5. Liang Wang#, Chunling Wu#, Wanling Peng , Ziliang Zhou, Jianzhi Zeng, Xuelin Li, Yini Yang, Shuguang Yu, Ye Zou, Mian Huang, Chang Liu, Yefei Chen , Yi Li, Panpan Ti, Wenfeng Liu, Yufeng Gao, Wei Zheng, Haining Zhong, Shangbang Gao, Zhonghua Lu, Pei-Gen Ren, Ho Leung Ng, Jie He, Shoudeng Chen, Min Xu, Yulong Li, Jun Chu*,"A high-performance genetically encoded fluorescent indicatorfor in vivo camp imaging", Nature Communications,13: 5363, (2022).
6. Xiaobo Li#, Jinghua Pan#, Tongzheng Liu#, Wenqian Yin, Qun Miao, Zhan Zhao,Yufeng Gao, Wei Zheng, Hang Li, Rong Deng, Dandan Huang, Shenghui Qiu,Yiran Zhang, Qi Qi, Lijuan Deng, Maohua Huang, Patrick Ming-Kuen Tang,Yihai Cao* , Minfeng Chen*, Wencai Ye* and Dongmei Zhang*, “Novel TCF21high pericyte subpopulation promotes colorectal cancer metastasis by remodelling perivascular matrix”, Gut, 2022;0:1-12, (2022) .
2021
1. Hui Li#, Yixuan Yin#, Feng Xiang, Jia Yu, Ting Wu, Lina Liu, Jiuling Liao, and Wei Zheng*,"Label-free characterization of ischemic cerebral injury using intravital two-photon excitation fluorescence lifetime imaging microscopy", Journal of Physics D: Applied Physics, 54: 114001, (2021).
2. Rongli Zhang, Zhongbiao Xu, Junhai Hao, Jia Yu, Zhiyi Liu, Shun Liu, Wanwen Chen, Jiahui Zhou, Hui Li*, Zhanyi Lin*, and Wei Zheng*,"Label-free identification of human coronary atherosclerotic plaque based on three-dimensional quantitative assessment of multiphoton microscopy images", Biomedical Optics Express, 12(5):2979-2995, (2021).
3. Jiuling Liao, Lina Liu, Tingai Chen, Xianyuan Xia, Hui Li, and Wei Zheng*,"Comparison of Two- and Three-Beam Interference Pattern Generation in Structured Illumination Microscopy", Photonics, 8(12), 526, (2021).
2020
1. Jiuling Liao, Yixuan Yin, Jia Yu, Rongli Zhang, Ting Wu, Hui Li, Qinchao Sun, Labao Zhang*, and Wei Zheng*,"Depth-resolved NIR-II fluorescence mesoscope ", Biomedical Optics Express, 11(5): 2366-2372, (2020).
2. Jia Yu#, Rongli Zhang#, Yufeng Gao, Zonghai Sheng, Min Gu, Qinchao Sun, Jiuling Liao, Ting Wu, Zhanyi Lin, Peiheng Wu, Lin Kang, Hui Li*, Labao Zhang*, and Wei Zheng*, “Intravital confocal fluorescence lifetime imaging microscopy in second near-infrared window”, Optics Letters, 45(12): 3305-3308, (2020).
3. Ting Wu#, Jiuling Liao#, Jia Yu, Yufeng Gao, Hui Li, Jiarui Wu, Xianyuan Xia, Kebin Shi*, Wei Zheng*. “In vivo label-free two-photon excitation autofluorescence microscopy of microvasculature using a 520 nm femtosecond fiber laser”, Optics Letters, 45(10): 2704-2707, (2020).
4. Shiwei Ye, Yixuan Yin, Jing Yao, Jun Nie, Yuchen Song, Yufeng Gao, Jia Yu, Hui Li, Peng Fei*, and Wei Zheng*,"Axial resolution improvement of two-photon microscopy by multi-frame reconstruction and adaptive optics", Biomedical Optics Express, 11(11): 6634-6648, (2020).
5. Yufeng Gao, Lina Liu, Yixuan Yin, Jiuling Liao, Jia Yu, Ting Wu, Shiwei Ye, Hui Li*, and Wei Zheng*,"Adaptive optics via pupil ring segmentation improves spherical aberration correction for two-photon imaging of optically cleared tissues", Optics Express, 28(23): 34935-34947, (2020).
2019
1. Hui Li, Jia Yu, Rongli Zhang, Xi Li and Wei Zheng*, “Two-photon excitation fluorescence lifetime imaging microscopy: A promising diagnostic tool for digestive tract tumors”, Journal of Innovative Optical Health Sciences, 12(5), 1930009, (2019).
2. Hui Li#, Meng Yan#, Jia Yu, Qiang Xu, Xianyuan Xia, Jiuling Liao and Wei Zheng*，”In vivo identification of arteries and veins using two-photon excitation elastin autofluorescence”, Journal of Anatomy, 236: 171-179, (2019).
3. Jiuling Liao#, Longchao Chen#, Xianyuan Xia#, Jia Yu, Tingai Chen, Hui Li, Wei Zheng*, “Multicolor re-scan super-resolution imaging of live cells”, Quantitative Imaging in Medicine and Surgery, 9(5):815-822, (2019).
4. Chengbo Liu#, Jiuling Liao#, Longchao Chen, Jianhua Chen, Rubo Ding, Xiaojing Gong, Caimei Cui, Zhiqiang Pang, Wei Zheng*, Liang Song*, "The integrated high-resolution reflection-mode photoacoustic and fluorescence confocal microscopy." Photoacoustics, V14, 12-18 (2019).
5. Qiqi Sun*, Wei Zheng, Chao Lin and Dongxuan Shen, “A Low-Cost Micro-Volume Nephelometric System for Quantitative Immunoagglutination Assays”, Sensors, 19(20), 4359, (2019).
6. Huichao Zhou#, Ningbo Chen#, Huangxuan Zhao, Tinghui Yin, Jianhui Zhang, Wei Zheng, Liang Song, Chengbo Liu*, Rongqin Zheng*, “Optical-resolution photoacoustic microscopy for monitoring vascular normalization during anti-angiogenic therapy ”, Photoacoustics, 15: 100143, (2019).
7. Huangxuan Zhao, Ke Li, Ziwen Ke, Ningbo Chen, Songjian Wang, Ke Li, Lidai Wang, Xiaojing Gong, Wei Zheng, Liang Song, Zhicheng Liu*, Dong Liang*, Chengbo Liu*, “A new deep learning method for image deblurring in optical microscopic systems”. Journal of Biophotonics, e201960147, (2019).
2018
1. Xi Li#, Hui Li#, Xingzhen He, Tingai Chen, Xianyuan Xia, Chunxia Yang, and Wei Zheng*, “Spectrum- and time-resolved endogenous multiphoton signals reveal quantitative differentiation of premalignant and malignant gastric mucosa”, Biomedical Optics Express, V9(2), 453-471 (2018).
2. Wei Qin#, Pengfei Zhang#, Hui Li#, Jacky W. Y. Lam, Yuanjing Cai, Ryan T. K. Kwok, Jun Qian, Wei Zheng and Ben Zhong Tang*, "Ultrabright red AIEgens for two-photon vascular imaging with high resolution and deep penetration", Chemical Science, 2018, 9, 2705-2710, (2018).
3. Wei Song#, Yuli Wu#, Yufeng Gao, Tingai Chen, Wei Zheng, Hui Fang*, Liang Song* and Xiaocong Yuan, "Flexibly adjustable depth-of-focus photoacoustic microscopy with spatial light modulation", Applied Physics Letters,113,163502 (2018).
4. Fan Yang#, Wei Song#, Chonglei Zhang*, Changjun Min, Hui Fang, Luping Du, Peng Wu, Wei Zheng, Changhui Li, Siwei Zhu and Xiaocong Yuan *, "Broadband graphene-based photoacoustic microscopy with high sensitivity", Nanoscale,10(18): 8606-8614, (2018).
2017
1. Wei Zheng*, Yicong Wu, Peter Winter, Robert Fischer, Damian Dalle Nogare, Amy Hong, Chad McCormick, Ryan Christensen, William P Dempsey, Don B Arnold, Joshua Zimmerberg, Ajay Chitnis, James Sellers, Clare Waterman & Hari Shroff,” Adaptive optics improves multiphoton super-resolution imaging”, Nature Methods, V14, 869–872 (2017).
2. J. Li, H. Jahr, Wei Zheng, P.G. Ren, "Visualizing Angiogenesis by Multiphoton Microscopy In Vivo in Genetically Modified 3D-PLGA/nHAp Scaffold for Calvarial Critical Bone Defect Repair", Journal of Visualized Experiments, V127, doi:10.3791/55381, (2017).
2016
1. Jing Zhang, Lin Ren, Xi Mei, Qiang Xu, Wei Zheng* and Zhicheng Liu*,” Microstructure visualization of conventional outflow pathway and finite element modeling of trabecular meshwork”，BioMedical Engineering OnLine，V15, 162, (2016).
2. Wei Song#, Qiang Xu#, Yang Zhang, Yang Zhan, Wei Zheng*, Liang Song*, "Fully integrated reflection-mode photoacoustic, two-photon, and second harmonic generation microscopy in vivo", Scientific Reports, V6, 32240, (2016).
3. Jian Li#, Qiang Xu#, Bin Teng, Chen Yu, Jian Li, Liang Song, Yuxiao Lai, Jian Zhang, Wei Zheng*, Peigen Ren*, "Investigation of angiogenesis in bioactive 3-dimensional poly(d,l-lactide-co-glycolide)/nano-hydroxyapatite scaffolds by in vivo multiphoton microscopy in murine calvarial critical bone defect", Acta Biomaterialia, V42, 389-399 (2016).
2015
1. Xi Mei, Lin Ren, Qiang Xu, Wei Zheng*, Zhicheng Liu*,” Effect of persistent high intraocular pressure on microstructure and hydraulic permeability of trabecular meshwork’, Chinese Physics B, V24(5), 058701 (2015).
2. Qiqi Sun, Wei Zheng, Jiannong Wang, Yi Luo, Jianan Y. Qu*, “Mechanism of two-photon excited hemoglobin fluorescence emission,” Journal of Biomedical Optics, V20(10), 105014 (2015).
3. Riqiang Lin#, Jianhua Chen#, Huina Wang, Meng Yan, Wei Zheng, and Liang Song*, "Longitudinal label-free optical-resolution photoacoustic microscopy of tumor angiogenesis in vivo ," Quantitative Imaging in Medicine and Surgery, 5, 23-29 (2015).
2014
1. Wei Song#, Wei Zheng#, Ruiming. Liu#, Riqiang. Lin, Huina Huang, Xiaojing Gong, Shousheng Yang, Rui Zhang and Liang Song,” Reflection-mode in vivo photoacoustic microscopy with subwavelength lateral resolution”, Biomedical Optics Express, V5, 4235-4241 (2014).
2013
1. Shenkun Zheng#, Wei Zheng#, Shuxia Li, Dong Li, Yan Zeng, Yanqi Yang, Jianan Y. Qu. “Multimodal nonlinear optical microscopy improves the accuracy of early diagnosis of squamous intraepithelial neoplasia”, Journal of Biomedical Optics, V.18, 036001 (2013).
2012
1. Yan Zeng, Yun Wu, Dong Li, Wei Zheng, Wen-Xiong Wang and Jianan Y. Qu, "Two-photon excitation chlorophyll fluorescence lifetime imaging: a rapid and noninvasive method for in vivo assessment of cadmium toxicity in a marine diatom Thalassiosira weissflogii", Planta,V.236,1653-1663,(2012).
2011
1. Wei Zheng, Dong Li, Shuxia Li, Yan Zeng, Yanqi Yang and Jianan Y. Qu, "Diagnostic value of nonlinear optical signals from collagen matrix in the detection of epithelial precancer", Optics Letters, V.36, 3620-3623 (2011).
2. Dong Li#, Wei Zheng#, Wei Zhang, Seng Khoon Teh, Yan Zeng, Yi Luo and Jianan Y. Qu, "Time-resolve detection enables standard two-photon fluorescence microscope for in vivo label-free imaging of microvasculature in tissue", Optics Letters, V.36, 2638-2640 (2011).
3. Wei Zheng#, Dong Li#, Yan Zeng, Yi Luo and Jianan Y. Qu, "Two-photon excited hemoglobin fluorescence", Biomedical Optics Express, V.2, 71-79 (2011).
4. Dong Li#, Wei Zheng#, Yan Zeng, Yi Luo and Jianan Y. Qu, "Two-photon excited hemoglobin fluorescence provides contrast mechanism for label-free imaging of microvasculature in vivo ", Optics Letters, V.36, 834-836 (2011).
5. Yan Zeng, Liguo Jiang, Wei Zheng, Dong Li, Shuhuai Yao and Jianan Y. Qu, "Quantitative imaging of mixing dynamics in microfluidic droplets using two-photon fluorescence lifetime imaging", Optics Letters, V.36, 2236 (2011).
Before 2011
1. Wei Zheng, Dong Li and Jianan Y. Qu, "Monitoring changes of cellular metabolism and micro-viscosity in vitro based on time-resolved endogenous fluorescence and its anisotropy decay dynamics", Journal of Biomedical Optics, V.15, 037013 (2010).
2. Dong Li, Wei Zheng, Yan Zeng and Jianan Y. Qu, "In vivo and simultaneous multimodal imaging: integrated multiplex CARS and two-photon microscopy", Applied Physics Letters, V.97, 223702 (2010).
3. Zhe Wang, Tao Wu, Lin Shi, Lin Zhang, Wei Zheng, Jianan Y. Qu, Ruifang Niu and Robert Z. Qi, "Conserved Motif of CDK5RAP2 Mediates Its Localization to Centrosomes and the Golgi Complex", Journal of Biological Chemistry, V. 285, 22658 (2010).
4. Dong Li, Wei Zheng and Jianan Y. Qu, "Imaging of epithelial tissue in vivo based on excitation of multiple endogenous nonlinear optical signals", Optics Letters, V.34, 2853-2855 (2009).
5. Dong Li, Wei Zheng and Jianan Y. Qu, "Two-photon autofluorescence microscopy of multicolor excitation", Optics Letters, V.34, 202-204 (2009).
6. Dong Li, Mildred S. Yang, Tao Lin, Wei Zheng and Jianan Y. Qu, "Study of cadmium induced cytotoxicity using two-photon excitation endogenous fluorescence microscopy", Journal of Biomedical Optics, V.14, 054028 (2009).
7. Wei Zheng, Yicong Wu, Dong Li and Jianan Y. Qu, "Epithelial autofluorescence: single- versus two-photon excitation", Journal of Biomedical Optics, V.13, 054010 (2008).
8. M.S. Yang, D. Li, T. Lin, J.J. Zheng, Wei Zheng and Jianan Y. Qu, "Increase in intracellular free/bound NAD[P]H as a cause of Cd-induced oxidative stress in the HepG2 cells ", Toxicology, V.247, 6-10 (2008).
9. Dong Li, Wei Zheng and Jianan Y. Qu, "Time-resolved spectroscopic imaging reveals the fundamentals of cellular NADH fluorescence", Optics Letters, V.33, 2365-2367 (2008).
10. Yicong Wu, Wei Zheng and Jianan Y. Qu, "Sensing cell metabolism by time-resolved autofluorescence", Optics Letters, V.31, 3122-3124 (2006).
(# equal contribution, *corresponding author)
科研项目
国家自然科学基金，国家重大科研仪器研制项目，81927803，活体多脑区神经活动光学成像同步检测系统研究，2020/01——2024/12，主持
国家自然科学基金，优秀青年基金，81822023，生物医学光子学，2019 /01－2021/12，主持
国家自然科学基金，重大研究计划培育项目，91959121 基于多光子成像的脑胶质瘤微环境演进过程三维高分辨可视化研究，2020/01－2022/12，主持
科技部重点研发计划，数字诊疗专项，2017YFC0110200，双光子-受激发射损耗（STED）复合显微镜，2017/07-2021/12，主持
深圳市基础研究，学科布局，JCYJ20170818164343304，生物细胞信息高分辨成像理论及动态显示技术研究，2018/03－2021/03，主持
深圳市基础研究，学科布局，JCYJ20180507182432303，无物理切割快速三维病理成像技术与方法研究，2019/03－2022/03，参与